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In vitro metabolic interactions between black cohosh ( Cimicifuga racemosa ) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4

✍ Scribed by Li, Jinghu; Gödecke, Tanja; Chen, Shao-Nong; Imai, Ayano; Lankin, David C.; Farnsworth, Norman R.; Pauli, Guido F.; van Breemen, Richard B.; Nikolić, Dejan


Book ID
118044269
Publisher
Informa plc
Year
2011
Tongue
English
Weight
934 KB
Volume
41
Category
Article
ISSN
0049-8254

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Metabolism of Dextromethorphan in vitro:
✍ JÜRGEN SCHMIDER; DAVID J. GREENBLATT; STEVEN M. FOGELMAN; LISA L. VON MOLTKE; RI 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB 👁 1 views

Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab