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Redesigning the substrate specificity of the hepatitis C virus NS3 protease

✍ Scribed by Cristina Maria Failla; Elisabetta Pizzi; Raffaele De Francesco; Anna Tramontano

Book ID
114382552
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
401 KB
Volume
1
Category
Article
ISSN
1359-0278

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Hepatitis C virus (HCV) NS3 protease is responsible for the processing of the viral polyprotein and is considered as a primary target for the development of anti-HCV therapy. We have developed a genetic method in yeast to screen for good substrate sequences of the NS3 protease. A library of fusion p