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Assessment of Substrate Specificity of Hepatitis G Virus NS3 Protease by a Genetic Method

โœ Scribed by Yong Jae Lee; Hara Kang; Seong-Hwan Rho; Soo Hyun Eom; Woo Jin Park

Book ID
115588413
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
176 KB
Volume
286
Category
Article
ISSN
0006-291X

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Hepatitis C virus (HCV) NS3 protease is responsible for the processing of the viral polyprotein and is considered as a primary target for the development of anti-HCV therapy. We have developed a genetic method in yeast to screen for good substrate sequences of the NS3 protease. A library of fusion p