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Conformational Stability of Hepatitis C Virus NS3 Protease

✍ Scribed by Abian, Olga; Vega, Sonia; Neira, Jose Luis; Velazquez-Campoy, Adrian


Book ID
119207644
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
541 KB
Volume
99
Category
Article
ISSN
0006-3495

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A novel radiometric in vitro assay for discovery of inhibitors of hepatitis C viral protease activity, suitable for high-throughput screening, was developed. The NS3 protein of hepatitis C virus (HCV) contains a serine protease, whose function is to process the majority of the nonstructural proteins