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Red cell pyruvate kinase deficiency: molecular and clinical aspects

✍ Scribed by Alberto Zanella; Elisa Fermo; Paola Bianchi; Giovanna Valentini

Book ID
108673215
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
355 KB
Volume
130
Category
Article
ISSN
0007-1048

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## Abstract Pyruvate kinase deficient red blood cells have an abnormal tendency to lose ATP when exposed to low pO~2~ or cyanide, whereas normal red cells do not. Once energy is depleted, all red cells take up calcium and subsequently lose intracellular potassium and water. It has been shown previo