𝔖 Bobbio Scriptorium
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Red cell pyruvate kinase deficiency: from genetics to clinical manifestations

✍ Scribed by Alberto Zanella; Paola Bianchi


Book ID
119754937
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
393 KB
Volume
13
Category
Article
ISSN
1521-6926

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## Abstract Pyruvate kinase deficient red blood cells have an abnormal tendency to lose ATP when exposed to low pO~2~ or cyanide, whereas normal red cells do not. Once energy is depleted, all red cells take up calcium and subsequently lose intracellular potassium and water. It has been shown previo