Red cell glyoxalase I (E.C.: 4.4.1.5): Formal genetics and linkage relations
✍ Scribed by J. Kömpf; S. Bissbort; H. Ritter
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 109 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
The segregation of GLO-phenotypes was analysed in 119 families with 266 children. The results are in agreement with the formal two-allele-model. Close linkage was ruled out for a number of informative markers.
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The polymorphism of glyoxalase I was investigated in 169 mother-child combinations from southwestern Germany. Glyoxalase I (GLO) has 3 common phenotypes: GLO 1, GLO 2-1, and GLO 2. The results are in good agreement with the formal hypothesis: Two alleles GLO1 and GLO2 at an autosomal locus. The GLO1
1025 individuals from Southern Germany were examined. The gene frequencies for GLI1 are 0.4235 and for GLI2 0.5765. These frequencies are compared with those of other authors.
One hundred and sixty-seven blood donors, 26 families with 72 offspring and 12 motherchild couples were studied for the phosphoglycolate phosphatase polymorphism. In hemolysates, the isozymes are stable for at least five weeks. The distribution of observed phenotypes in the population study did not