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Red blood cell alloimmunization in sickle cell disease patients in Uganda

โœ Scribed by Bernard Natukunda; Henk Schonewille; Christopher Ndugwa; Anneke Brand

Book ID
109144768
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
74 KB
Volume
50
Category
Article
ISSN
0372-1248

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The transfusion histories over a 33-month period of 50 patients with sickle cell disease were reviewed to determine the frequency of alloimmunization to red cell antigens following transfusion in these patients. There were 30 females and 20 males, aged 19--49 years. Eighteen (36%) were immunized of

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Sickle cell disease (SCD) patients are prone to develop complications that include stroke, acute chest syndrome, and other crises. Some of these complications require chronic transfusion therapy or red cell exchange (RCE), either for therapeutic or prophylactic reasons. Due to a discrepancy of red c