The transfusion histories over a 33-month period of 50 patients with sickle cell disease were reviewed to determine the frequency of alloimmunization to red cell antigens following transfusion in these patients. There were 30 females and 20 males, aged 19--49 years. Eighteen (36%) were immunized of
HLA type and risk of alloimmunization in sickle cell disease
โ Scribed by Carolyn Hoppe; William Klitz; Elliott Vichinsky; Lori Styles
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 418 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0361-8609
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๐ SIMILAR VOLUMES
Patients with sickle cell disease (SCD) form immune alloantibodies more frequently than other transfused populations because red cells (RBCs) from white donors (with a higher incidence of certain Rh, Duffy, Kell, and Kidd blood group antigens) are transfused to black patients often lacking these ant
Red blood cell (RBC) transfusions are widely used in the management of patients with sickle cell disease (SCD). However, repeated RBC transfusions are often complicated by RBC alloimmunization. To investigate whether the frequency of RBC alloimmunization could be accounted for by racial and RBC phen