Sickle cell anemia and the related hemoglobinopathies are associated with a large spectrum of renal abnormalities. The patients have impaired urinary concentrating ability, defects in urinary acidification and potassium excretion, and supranormal proximal tubular function. The latter is manifest by
Cytokine profile of sickle cell disease in Oman
โ Scribed by Anil Pathare; Salam Al Kindi; Adel Alwan Alnaqdy; Shahina Daar; Huxley Knox-Macaulay; David Dennison
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 87 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0361-8609
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Sickle cell disease is the most common inherited disorder in African-Americans. Although the primary defect is hematological, the changes in the erythrocytes lead to a vasculopathy with multiorgan injury. The pulmonary complications, i.e., acute chest syndrome and chronic sickle cell lung disease, a
Antiphospholipid antibody formation can be Induced In mice by phospholipid In a hexagonal II phase but not by phospholipid in a bllayer phase. Since sickle red cell membranes have increased hexagonal I1 phase content, we have measured serum antiphospholipid antibody levels in 25 patients with sickle