Leg ulcers in sickle cell disease
โ Scribed by Caterina P. Minniti; James Eckman; Paola Sebastiani; Martin H. Steinberg; Samir K. Ballas
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 110 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0361-8609
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๐ SIMILAR VOLUMES
Sickle cell anemia and the related hemoglobinopathies are associated with a large spectrum of renal abnormalities. The patients have impaired urinary concentrating ability, defects in urinary acidification and potassium excretion, and supranormal proximal tubular function. The latter is manifest by
Sickle cell disease is the most common inherited disorder in African-Americans. Although the primary defect is hematological, the changes in the erythrocytes lead to a vasculopathy with multiorgan injury. The pulmonary complications, i.e., acute chest syndrome and chronic sickle cell lung disease, a