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Hydroxyurea and sickle cell leg ulcers

โœ Scribed by Colleen Kersgard; Michael B. Osswald


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
62 KB
Volume
68
Category
Article
ISSN
0361-8609

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Use of hydroxyurea (HU) to treat sickle cell disease is usually associated with increments in fetal hemoglobin (Hb F) production; however, in vitro studies show that HU may also induce hemoglobin denaturation. Whole blood samples from Hb AA, Hb AS, and Hb SS patients were treated in vitro with 100,