✦ LIBER ✦

Post-transfusion alloimmunization in patients with sickle cell disease

✍ Scribed by Armando R. Orlina; Phyllis J. Unger; Mabel Koshy

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 339 KB
Volume: 5
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830050204

No coin nor oath required. For personal study only.

✦ Synopsis

The transfusion histories over a 33-month period of 50 patients with sickle cell disease were reviewed to determine the frequency of alloimmunization to red cell antigens following transfusion in these patients. There were 30 females and 20 males, aged 19--49 years. Eighteen (36%) were immunized of which thirteen were females. Five of the patients have formed only one antibody so far, while the other 13 have formed two or more. Thirty-six antibodies were identified: 16 against various Rh antigens, 12 anti-Lewis, 5 anti-Kell and one each of anti-Jka, -Fya and -M. The immunized patients received, on the average, more transfusions although there was a considerable degree of overlap between the immunized and nonimmunized groups. An approach to the hemotherapy of patients with sickle cell disease (SCD) is discussed.

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