Recurrent abnormalities of chromosome bands 10q23–25 in non-Hodgkin's lymphoma

✍ Scribed by Susan L. Speaks; Warren G. Sanger; Aneal S. Masih; Douglas S. Harrington; Michelle Hess; James O. Armitage

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 518 KB
• Volume: 5
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870050311

✦ Synopsis

Many nonrandom chromosome abnormalities have been associated with non-Hodgkin's lymphomas (NHL). Some of these are nonspecific changes seen in many different histologic subtypes. W e describe a series of abnormalities of chromosome bands lOq23-25 seen in 159 consecutive NHL patients with abnormal cytogenetic findings. The proportion of karyotypes with abnormalities of IOq varied from 3% among the immunoblastic lymphomas to 67% in the diffuse large cleaved cell lymphomas. Seventeen (10.7%) had abnormalities of I Oq23-25. All but one of these were 6-cell tumors. The abnormalities consisted of six deletions and I I translocations. Sixteen of the 17 patients had the IOq abnormality when cells were first karyotyped. The remaining patient acquired the I Oq abnormality in the third of a series of biopsies. In the follicular histologic subtypes [follicular small cleaved cell (FSC), follicular mixed small cleaved and large cell (FM), and follicular large cell noncleaved (FL-NC)]. abnormalities of I Oq were found in nine patients, all in association with abnormalities of I4q32. Seven of these were associated with the t( 14; 18)(q32;q2 I). Overall, I Oq23-25 abnormalities were observed in I I .9% (8/67) of low-grade [small lymphocytic (SL), FSC, and FM] lymphoma cases. DNA was available from five patients with abnormalities of IOq and was probed for rearrangements with the HOXl I (TCU) oncogene probe. As expected, we did not find such rearrangements in these five patients with 6-cell tumors. Abnormalities of lOq23-25 have been reported previously in NHL but not at this frequency. Genes