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Recovery of ornithine decarboxylase activity after inhibition with α-difluoromethylornithine

✍ Scribed by John L.A. Mitchell; Robert J. Kurzeja; John F. Marsh; Roger R. Diveley Jr.


Book ID
117055695
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
277 KB
Volume
187
Category
Article
ISSN
0006-291X

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A large body of evidence exists suggesting that polyamines can play essential roles in cellular growth and differentiation. We examined the ability of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the major rate-limiting enzyme in polyamine biosynthesis,