Inhibition of murine embryonic development by α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase
✍ Scribed by John R. Fozard; Marie-Louise Part; Nellikunja J. Prakash; Jeffrey Grove
- Book ID
- 115876169
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 929 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0014-2999
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In the present study, the effect of D,L-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), on Friend's murine erythroleukemia (MEL) cell differentiation is investigated. DFMO was able to induce differentiation of MEL cells in culture as determined by ha
A large body of evidence exists suggesting that polyamines can play essential roles in cellular growth and differentiation. We examined the ability of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the major rate-limiting enzyme in polyamine biosynthesis,