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Inhibition of ornithine decarboxylase activity by small doses of α-difluoromethylornithine

✍ Scribed by Loprinzi, C.L.; Verma, A.K.

Book ID
123251364
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
435 KB
Volume
28
Category
Article
ISSN
0304-3835

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✍ Michael A. Pfaller; Tim Gerarden; John Riley 📂 Article 📅 1987 🏛 Springer Netherlands 🌐 English ⚖ 687 KB

A large body of evidence exists suggesting that polyamines can play essential roles in cellular growth and differentiation. We examined the ability of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the major rate-limiting enzyme in polyamine biosynthesis,