The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V H gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V H genes regulates their recombination potential, hence alterations in chromat
Reconsidering the human immunoglobulin heavy-chain locus:
✍ Scribed by C. E. H. Lee; B. Gaëta; H. R. Malming; M. E. Bain; W. A. Sewell; A. M. Collins
- Book ID
- 105947657
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 133 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0093-7711
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During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear