Previous experiments using rat/mouse somatic cell hybrids have localized the rat c-myc gene to chromosome 7 (Siimegi et al. 1983), the rat immunoglobulin kappa locus to chromosome 4 (Perlmann et al. 1985), and the rat immunoglobulin heavy chain locus to chromosome 6 (Pear et al. 1986). Using a simil
Localization of the rat immunoglobulin heavy chain locus to chromosome 6
✍ Scribed by Warren S. Pear; Gunilla Wahlström; Josiane Szpirer; Göran Levan; George Klein; Janos Sümegi
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 288 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
We have previously used rat/mouse somatic cell hybrids to localize the rat c-myc gene to chromosome 7 (Siimegi et al. 1983) and the rat immunoglobulin kappa locus to chromosome 4 (Perlmann et al. 1985). We now report that by utilizing rat/mouse somatic cell hybrids, we have localized the rat immunoglobulin heavy chain locus to chromosome 6.
📜 SIMILAR VOLUMES
The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V H gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V H genes regulates their recombination potential, hence alterations in chromat