Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat
β Scribed by Jacobus Hendricks; Peter Terpstra; Peter M. Dammers; Rajesh Somasundaram; Annie Visser; Maaike Stoel; Nicolaas A. Bos; Frans G. M. Kroese
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 389 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0093-7711
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During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear
We have previously used rat/mouse somatic cell hybrids to localize the rat c-myc gene to chromosome 7 (Siimegi et al. 1983) and the rat immunoglobulin kappa locus to chromosome 4 (Perlmann et al. 1985). We now report that by utilizing rat/mouse somatic cell hybrids, we have localized the rat immunog