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Evolutionary dynamics of the immunoglobulin heavy chain variable region genes in vertebrates

โœ Scribed by Sabyasachi Das; Masafumi Nozawa; Jan Klein; Masatoshi Nei


Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
330 KB
Volume
60
Category
Article
ISSN
0093-7711

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## Abstract Postโ€transplant lymphoproliferative disorders (PTLD) derive from antigenโ€experienced Bโ€cells and represent a major complication of solid organ transplantation. We characterized usage, mutation frequency and mutation pattern of immunoglobulin variable (IGV) gene rearrangements in 50 PTLD