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Recombinant interleukin 2 enhances spontaneous insulin-dependent diabetes in BB rats

✍ Scribed by Hubert Kolb; Jürgen Zielasek; Ulrich Treichel; Götz Freytag; Michael Wrann; Ulrich Kiesel

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 508 KB
Volume: 16
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830160218

No coin nor oath required. For personal study only.

✦ Synopsis

Recombinant interleukin 2 enhances spontaneous insulin-dependent diabetes in BB rats*

Treatment of BB rats with recombinant interleukin 2 (IL2) enhanced the development of spontaneous diabetes in these animals. A dose of 20 pg IL2ikg body weight was administered twice daily for 80 days starting at 42 days of age. The rate of diabetes was doubled after IL2 administration (53% vs.23%) and the onset of diabetes was found to be accelerated by a mean of 18 days. Histological analysis showed enhanced inflammation of islets and in addition interstitial pancreatis. It is concluded that IL 2 has a regulatory effect on spontaneous organ-specific autoimmunity.

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