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Spontaneous diabetes in BB rats: Evidence for a T cell dependent immune response defect

✍ Scribed by D. Bellgrau; A. Naji; W. K. Silvers; J. F. Markmann; C. F. Barker

Publisher
Springer
Year
1982
Tongue
English
Weight
616 KB
Volume
23
Category
Article
ISSN
0012-186X

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✦ Synopsis

Approximately 50% of BB rats develop insulinopenic hyperglycaemia and ketosis spontaneously in association with insulitis. Amelioration of the syndrome by immunosuppression suggests a cell mediated immune pathogenesis. Analysis of the cell-mediated immune profile of overtly diabetic and normoglycaemic diabetes prone BB rats indicates that they are lymphocytopenic relative to non-diabetes prone BB rats and that the T cell pool is particularly affected. Furthermore, lymphocytes from diabetic and diabetes prone BB rats, while producing normal responses to the T cell mitogen concanavalin A, do not respond when mixed in vitro with major histocompatibility complex incompatible lymphocytes. This anergy is not restored either by enriching the responding cell population for T cells or by adding exogenous T cell growth promoting factor. Thus BB rats have a numerical and regulatory deficit of their T cells which could be related to their propensity for diabetes.

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✍ Robert L. Lundak; Marvin S. Kaplan; Donald J. Raidt; Tina S. Hronis; Gale A. Gra πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 English βš– 380 KB πŸ‘ 1 views

## Abstract Immunocompetent lymphoid cells cultured in vitro with allogeneic stimulator cells have been shown to produce T‐lymphocyte populations which are specifically cytotoxic in vitro to the stimulatory cells whether normal or malignant. Although the culture requirements as well as the allogene