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Recombinant human interleukin-1α and recombinant human interleukin-1β stimulate cartilage matrix degradation and inhibit glycosaminoglycan synthesis

✍ Scribed by Robert J. Smith; Norman A. Rohloff; Laurel M. Sam; James M. Justen; Martin R. Deibel; James C. Cornette

Publisher
Springer
Year
1989
Tongue
English
Weight
767 KB
Volume
13
Category
Article
ISSN
0360-3997

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✍ Ilana Yaron; Frank A. Meyer; Jean-Michel Dayer; Ilan Bleiberg; Michael Yaron 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 670 KB

Recombinant human cytokines were compared for their effects on glycosaminoglycan (GAG) synthesis in human synovial fibroblast cultures and human articular cartilage explant cultures. In fibroblast cultures, recombinant human interleukin-la (rHuIL-la), rHuIL-lP, and recombinant human tumor necrosis f