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Recognition and Inhibition of HIV Integrase by Novel Dinucleotides

โœ Scribed by Taktakishvili, Michael; Neamati, Nouri; Pommier, Yves; Pal, Suresh; Nair, Vasu


Book ID
126149467
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
229 KB
Volume
122
Category
Article
ISSN
0002-7863

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Recognition and inhibition of HIV integr
โœ Michael Taktakishvili; Nouri Neamati; Yves Pommier; Vasu Nair ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 140 KB

The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discov