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Recognition and inhibition of HIV integrase by a novel dinucleotide

✍ Scribed by Michael Taktakishvili; Nouri Neamati; Yves Pommier; Vasu Nair

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 140 KB
Volume: 10
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(99)00677-0

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✦ Synopsis

The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually novel dinucleotide, pIsodApdC, which is a potent inhibitor of this key viral enzyme.

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