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Design, Synthesis and Biological Evaluation of Novel Tricyclic HIV-1 Integrase Inhibitors by Modification of Its Pyridine Ring.

✍ Scribed by Sammy E. Metobo; Haolun Jin; Manuel Tsiang; Choung U. Kim


Publisher
John Wiley and Sons
Year
2006
Weight
10 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Abstract Two sets of compounds derived from the fusion of a diversely annulated naphthoxazepinedione system with 1,3‐thiazole and 1,3‐oxazole are described. These compounds are close analogues of previously reported thiazolothiazepine inhibitors of human immunodeficiency virus typeβ€…1 integrase (