Design, Synthesis and Biological Evaluat
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Daniel Spinks; Dr. Leah S. Torrie; Dr. Stephen Thompson; Dr. Justin R. Harrison;
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Article
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2011
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John Wiley and Sons
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English
โ 318 KB
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Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou