## Abstract ## Background HIVβ1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the __in vivo__ functions are not well characterized, it is thought that IN has pleiotropic effects and plays a central role in the interplay between the virus and the host cell. Expressi
HIV-1 Integrase Inhibition of Biscoumarin Analogues.
β Scribed by Chang-Xiao Su; Jean-Francois Mouscadet; Chih-Chia Chiang; Hou-Jen Tsai; Ling-Yih Hsu
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 10 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The HIVβ1 Integrase protein (IN) mediates the integration of the viral cDNA into the host genome. IN is an emerging target for antiβHIV drug design, and the first INβinhibitor was recently approved by the FDA. We have developed a new approach for inhibiting IN by βshiftidesβ: peptides d
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discov