Receptor regulation of the glutamate, GABA and taurine high-affinity uptake into astrocytes in primary culture
✍ Scribed by Elisabeth Hansson; Lars Rönnbäck
- Book ID
- 115802057
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 521 KB
- Volume
- 548
- Category
- Article
- ISSN
- 0006-8993
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Taurine uptake in cultured cerebellar granule cells and astrocytes consisted of a saturable high-affinity component and nonsaturable diffusion. The transport constant (Km) was significantly lower and the maximal velocity (V) higher in granule cells than in astrocytes. The uptakes were strictly sodiu
## Abstract Glutamate uptake into rat brain astrocytes is potently stimulated by addition of norepinephrine (NE). This effect is mediated by α~1~‐adrenergic receptors expressed by these cells (Hansson and Rönnbäck: Life Sci 44:27, 1989; Brain Res 548:215, 1991). The present study was undertaken in