Recent insights into the genetic basis of systemic lupus erythematosus
β Scribed by Moser, K L; Kelly, J A; Lessard, C J; Harley, J B
- Book ID
- 109852908
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 717 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1466-4879
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Antibodies against Ro and La, including recombinant La and recombinant 60 kD-Ro, were determined by counter immunoelectrophoresis and ELISA in over 300 central European systemic lupus erythematosus (SLE) patients. The presence of both Ro and La antibodies was strongly associated with the MHC haploty
Major advances in understanding the genetic foundation of systemic lupus erythematosus are in the offing. Genetic association studies suggest multiple effects that include those encoded by the HLA region, the genes for Fcgamma receptors and other genes such as that for the mannose-binding protein. G