𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Recent developments in MHC-class-I-mediated antigen presentation

✍ Scribed by Paul J Lehner; Peter Cresswell

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
188 KB
Volume
16
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

✦ Synopsis

Defective ribosomal products provide an important supply of endogenous peptides for entry into the classic MHC class I antigen presentation pathway. The recruitment of endoplasmic reticulum membrane during phagosome biogenesis allows exogenous antigens to be translocated into the cytosol as well as providing access to the class I peptide transport and loading machinery. This combination of features provides a mechanism for cross-presentation by specialised antigen presenting cells. Recent studies have shed new light on these pathways and have also described the emerging K3 family of viral ubiquitin E3 ligases, which constitutively ubiquitinate and degrade MHC class I molecules and other immunoreceptors.

πŸ“œ SIMILAR VOLUMES

Antigen processing for presentation by M
Antigen processing for presentation by MHC class I molecules
✍ Thomas J. Braciale πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 English βš– 505 KB

The association of peptide fragments with MHC class I molecules is believed to be a requirement for the assembly of the MHC class I molecules in the endoplasmic reticulum, and transportation of the MHC molecules from the endoplasmic reticulum to the cell surface. Recently, investigators have begun t

MHC class II signaling in antigen-presen
MHC class II signaling in antigen-presenting cells
✍ Reem Al-Daccak; Nuala Mooney; Dominique Charron πŸ“‚ Article πŸ“… 2004 πŸ› Elsevier Science 🌐 English βš– 983 KB

The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their

Differential presentation of tumor antig
Differential presentation of tumor antigen-derived epitopes by MHC-class I and antigen-positive tumor cells
✍ Gerhard Held; Frank Neumann; Christine Sturm; Lars Kaestner; Nina Dauth; Diederi πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 French βš– 311 KB

## Abstract SSX2 is a member of the family of cancer/testis antigens. The SSX2 derived peptide SSX2~103–111~ has been shown to be presented to cytotoxic T‐lymphocytes (CTL) by Major‐Histocompatibility (MHC) Class‐I complexes after endogenous processing, more precisely by the allele HLA‐A\*0201. The