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MHC class II signaling in antigen-presenting cells

✍ Scribed by Reem Al-Daccak; Nuala Mooney; Dominique Charron

Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 983 KB
Volume: 16
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2003.11.006

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✦ Synopsis

The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their role as antigen-presenting structures; they are flexible receptors that, by triggering a variety of signaling pathways, can regulate APC activities from proliferation and maturation to apoptosis. Recent advances have provided insights into how these molecules might accommodate such regulation.

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