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Cellular studies on antigen presentation by class II MHC molecules

โœ Scribed by Emil R. Unanue

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
976 KB
Volume
4
Category
Article
ISSN
0952-7915

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โœฆ Synopsis

Particularly prominent during the past year was the analysis of the subcellular compartment in which MHC class II molecules are located. Some investigators also analyzed the site where peptides are generated for MHC class II binding. Studies of invariant chain were particularly important in trying to establish the functional significance of this molecule.

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โœ Thomas J. Braciale ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 505 KB

The association of peptide fragments with MHC class I molecules is believed to be a requirement for the assembly of the MHC class I molecules in the endoplasmic reticulum, and transportation of the MHC molecules from the endoplasmic reticulum to the cell surface. Recently, investigators have begun t