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Inhibition of endogenous MHC class II-restricted antigen presentation by tacrolimus (FK506) via FKBP51

✍ Scribed by Akihito Imai; Hiroeki Sahara; Yasuaki Tamura; Kowichi Jimbow; Tamotsu Saito; Kyori Ezoe; Takatoshi Yotsuyanagi; Noriyuki Sato


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
327 KB
Volume
37
Category
Article
ISSN
0014-2980

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Toxoplasma gondii down-regulates MHC cla
✍ Carsten G. K. LΓΌder; Wolfgang Walter; Barbara Beuerle; Markus J. Maeurer; Uwe Gr πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 391 KB πŸ‘ 1 views

The obligate intracellular protozoan parasite Toxoplasma gondii is able to establish persistent infections within human and animal hosts. We have shown recently that T. gondii downregulates IFN-+ -induced MHC class II expression in murine bone marrow-derived macrophages (BMM ΒΆ ). As shown in this st