Recent Advances in Structure-Based Virtual Screening of G-Protein Coupled Receptors
โ Scribed by Subramaniam Ananthan; Wei Zhang; Judith Varady Hobrath
- Book ID
- 111767550
- Publisher
- American Association of Pharmaceutical Scientists
- Year
- 2009
- Tongue
- English
- Weight
- 229 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1550-7416
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Recent advances in the various genome-sequencing projects have opened the floodgates to thousands of protein sequences that are possibly new targets for drug discovery. [1] Accordingly, computer techniques are required for the reliable prediction of protein structures accurate enough to serve as a p
The ability of high throughput membrane binding assays to detect ligands for G-protein coupled receptors was examined using mathematical models. Membrane assay models were developed using the extended ternary complex model (Samama et al., 1993) as a basis. Ligand binding to whole cells was modeled b