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Shape-mimetics of G-protein-coupled receptors in therapeutic drug design and screening

โœ Scribed by Kristen Sadler; James P. Tam


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
286 KB
Volume
62
Category
Article
ISSN
0272-4391

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The ability of high throughput membrane binding assays to detect ligands for G-protein coupled receptors was examined using mathematical models. Membrane assay models were developed using the extended ternary complex model (Samama et al., 1993) as a basis. Ligand binding to whole cells was modeled b