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Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors

✍ Scribed by Debasis Das; Jian Hong; Shu-Hui Chen; Guangyi Wang; Leonid Beigelman; Scott D. Seiwert; Brad O. Buckman


Book ID
108073049
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
752 KB
Volume
19
Category
Article
ISSN
0968-0896

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2β€²-Deoxy-2β€²-Ξ±-fluoro-2β€²-Ξ²-C-methyl 3β€²,5β€²
✍ P. Ganapati Reddy; Donghui Bao; Wonsuk Chang; Byoung-Kwon Chun; Jinfa Du; Dhanap πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 808 KB

A series of novel 2 0 -deoxy-2 0 -a-fluoro-2 0 -b-C-methyl 3 0 ,5 0 -cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than the parent nucleoside in a cell-based replic