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A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase

✍ Scribed by Liu, Jian; Du, Jinfa; Wang, Peiyuan; Nagarathnam, Dhanapalan; Espiritu, Christine L.; Bao, Haiying; Murakami, Eisuke; Furman, Phillip A.; Sofia, Michael J.

Book ID
120288754
Publisher
Taylor and Francis Group
Year
2012
Tongue
English
Weight
196 KB
Volume
31
Category
Article
ISSN
0732-8311

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📜 SIMILAR VOLUMES

2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′
2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938
✍ P. Ganapati Reddy; Donghui Bao; Wonsuk Chang; Byoung-Kwon Chun; Jinfa Du; Dhanap 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 808 KB

A series of novel 2 0 -deoxy-2 0 -a-fluoro-2 0 -b-C-methyl 3 0 ,5 0 -cyclic phosphate nucleotide prodrug analogs were synthesized and evaluated for their in vitro anti-HCV activity and safety. These prodrugs demonstrated a 10-100-fold greater potency than the parent nucleoside in a cell-based replic