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Discovery of Pyrano[3,4- b ]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

✍ Scribed by Gopalsamy, Ariamala; Lim, Kitae; Ciszewski, Gregory; Park, Kaapjoo; Ellingboe, John W.; Bloom, Jonathan; Insaf, Shabana; Upeslacis, Janis; Mansour, Tarek S.; Krishnamurthy, Girija; Damarla, Murthy; Pyatski, Yelena; Ho, Douglas; Howe, Anita Y. M.; Orlowski, Mark; Feld, Boris; O'Connell, John


Book ID
120047760
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
105 KB
Volume
47
Category
Article
ISSN
0022-2623

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The Discovery of Pyrano[3,4-b]indole-Bas
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Hepatitis C (HCV) belongs to the Flaviviridae family of positivesense, single-stranded RNA viruses. The HCV genome encodes a polyprotein, comprised of 3000 amino acid residues, which is processed into both structural and nonstructural proteins. [1] HCV infection is a significant global health issue;