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Reactivity of Intein Thioesters: Appending a Functional Group to a Protein

✍ Scribed by Jeet Kalia; Ronald T. Raines

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
346 KB
Volume
7
Category
Article
ISSN
1439-4227

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✍ Michael A. Cole; Sarah E. Tully; Alister W. Dodds; James N. Arnold; Grant E. Bol πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 562 KB

## Abstract **Less than 6 feet under**: Serum proteins C3, C4, and Ξ±~2~M each contain a thioester domain buried within a hydrophobic pocket, which is thought to shield the labile thioester from hydrolysis. Herein, we make use of the inherent reactivity of the hydrazide for thioester moieties to che