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Cover Picture: A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in Their Native State (ChemBioChem 8/2009)

✍ Scribed by Michael A. Cole; Sarah E. Tully; Alister W. Dodds; James N. Arnold; Grant E. Boldt; Robert B. Sim; John Offer; Paul Wentworth Jr.

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 900 KB
Volume: 10
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.200990027

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A Chemical Approach to Immunoprotein Eng

A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in Their Native State

✍ Michael A. Cole; Sarah E. Tully; Alister W. Dodds; James N. Arnold; Grant E. Bol 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 562 KB

## Abstract **Less than 6 feet under**: Serum proteins C3, C4, and α~2~M each contain a thioester domain buried within a hydrophobic pocket, which is thought to shield the labile thioester from hydrolysis. Herein, we make use of the inherent reactivity of the hydrazide for thioester moieties to che