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Reactivity of Cyanogen towardsN-Substituted Sulfamides: Synthesis of 1,2,5-Thiadiazole 1,1-Dioxide Derivatives

✍ Scribed by Alkorta, Ibon ;Arán, Vicente J. ;Dávila, Elena ;Ruiz, José R. ;Stud, Manfred

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
306 KB
Volume
1989
Category
Article
ISSN
0947-3440

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✦ Synopsis

Aminoimino tautomerism 4-Amino-3-oxo-1,2,5-thiadiazole 1,l-dioxides 2 have been proposed as interesting "urea equivalent" fragments in the development of new histamine Hz-receptor antagonists". These compounds were previously prepared by a tedious multi-step procedure involving ring contraction of 4-(hydroxyimino)-3,5-dioxo-1,2,6-thiadiazine

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