Aminoimino tautomerism 4-Amino-3-oxo-1,2,5-thiadiazole 1,l-dioxides 2 have been proposed as interesting "urea equivalent" fragments in the development of new histamine Hz-receptor antagonists". These compounds were previously prepared by a tedious multi-step procedure involving ring contraction of 4
Synthesis and reactivity of some amino-substituted 1,2,5-thiadiazole 1,1-dioxides
✍ Scribed by Arán, Vicente J. ;Ruiz, José R. ;Dávila, Elena ;Alkorta, Ibon ;Stud, Manfred
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 568 KB
- Volume
- 1988
- Category
- Article
- ISSN
- 0947-3440
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## Abstract A synthetic pathway for obtaining arylamino, alkylamino 3,4‐disubstituted 1,2,5‐thiadiazole dioxide derivatives has been developed. This methodology could be applied to obtain potential biologically active molecules.
The hydrolysis reactions of 4-amino-2-phenethyl-and 4-amino-2-cyclohexyl-2,3-dihydro-3-oxo-1,2,5thiadiazole 1,1-dioxide (Ia and Ib) were investigated in the range 24-73 °C in buffered aqueous solutions. The observed rate constants (k obs ) are independent of pH in the range ca 1-4 pH, but increase w