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Reactivities of systemic lupus erythematosus sera with cellular and virus antigen preparations

✍ Scribed by Theodore Pincus; Alfred D. Steinberg; Neil R. Blacklow; John L. Decker

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
558 KB
Volume
21
Category
Article
ISSN
0004-3591

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Sera obtained from fifty-five patients with active systemic lupus erythematosus (SLE) and from four patients with mixed connective tissue disease (MCTD) previously shown by immunofluorescence and by double immunodiffusion to possess antinuclear antibodies, were tested for the presence of natural ant

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## Objective. The implied role of retroviruses in the pathogenesis of murine systemic lupus erythematosus (SLE) led us to study antiretroviral antibodies in a population-based SLE cohort. Methods. Immunoassays using whole virus and synthetic peptides were performed on sera from 72 patients with SL