Antibody a c t i v i t y t o various histones was examined i n a s o l i d phase radioimmunoassay. More than one h a l f o f the sera from systemic lupus erythematosus (SLE) p a t i e n t s had IgM a c t i v i t y t o t o t a l histones, and a s l i g h t l y lower frequency was observed f o r IgG a
Reactions of systemic lupus erythematosus sera with histone fractions and histone-DNA complexes
β Scribed by Dr. B. David Stollar
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 443 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0004-3591
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Sera obtained from fifty-five patients with active systemic lupus erythematosus (SLE) and from four patients with mixed connective tissue disease (MCTD) previously shown by immunofluorescence and by double immunodiffusion to possess antinuclear antibodies, were tested for the presence of natural ant
## Abstract Novel hydrolytic activity of the antiβhistone H1 antibodies (Ab) toward histone H1 and myelin basic protein (MBP) was shown. Blood serum of ten patients with clinically diagnosed systemic lupus erythematosus (SLE), and nine healthy donors (control) were screened for the antiβhistone H1