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Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production

✍ Scribed by Reinhard E. Voll; Edith A. Roth; Irute Girkontaite; Holger Fehr; Martin Herrmann; Hanns-Martin Lorenz; Joachim R. Kalden


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
966 KB
Volume
40
Category
Article
ISSN
0004-3591

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We describe a patient with systemic lupus erythematosus who, after a disease flare, sequentially produced antibodies to specific Sm polypeptides (demonstrated by counterimmunoelectrophoresis, immunoblotting, and RNA immunoprecipitation) concomitantly with the disappearance of anti-double-stranded DN