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Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II)

✍ Scribed by Aparna Jain; M. C. Martin; Nazneen Parveen; N. U. Khan; J. H. Parish; S. M. Hadi

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
84 KB
Volume
13
Category
Article
ISSN
0951-418X

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✦ Synopsis

DNA strand scission reactions of flavonoids in the presence of Cu(II) have been extended by using flavonoids with a variety of patterns of hydroxyl substitution. In particular we have examined for the first time a flavonoid (7,8-dihydroxyflavone) that lacks the possibility of forming a complex involving the oxygen at position 4. By comparing the reactivities of several flavonoids, including data from the literature, we draw generalizations for the correlation of structure and activity and present evidence for at least three different modes of action of flavonoids as genotoxic agents.

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Interactions of metallic ions with DNA.
Interactions of metallic ions with DNA. V. DNA Renaturation Mechanism in the Presence of Cu2+
✍ HΓ©lΓ¨ne Richard; J. P. Schreiber; M. Daune πŸ“‚ Article πŸ“… 1973 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 533 KB

## Abstract New experimental data were obtained by means of circular dichroism, melting, renaturation, and kinetic experiments, upon Cu^2+^ binding to DNA, poly dAT, and poly dGdC. They enable us to propose a model of binding giving a satisfactory explanation to all of the data found in the literat