Reactive oxygen species as mediators of the transformed phenotype

✍ Scribed by Juliane M. Jürgensmeier; Jens Panse; Reinhold Schäfer; Georg Bauer

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: French
• Weight: 64 KB
• Volume: 70
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19970304)70:5<587::aid-ijc16>3.0.co;2-a

✦ Synopsis

Reactive oxygen species (ROS) are known to be involved in different pro- and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage-independent growth of transformed murine fibroblasts is inhibited by antioxidants and radical scavengers in a concentration-dependent and reversible manner. These agents also reduce TGF-beta-dependent stimulation of colony formation in soft agar, pointing to their specific interference with TGF-beta-triggered signal chains involved in the maintenance of the transformed state.