Phagocyte-derived reactive oxygen species as suppressors of inflammatory disease

Expression of nitric oxide synthases and

Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease

✍ Dijkstra, Gerard; Moshage, Han; Van Dullemen, Hendrik M.; de Jager-Krikken, Alie 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 282 KB 👁 2 views

## Nitric oxide (NO) and reactive oxygen species (ROS) are important mediators in the pathogenesis of inflammatory bowel disease (IBD). NO in IBD can be either harmful or protective. NO can react with superoxide anions (O 2 • ), yielding the toxic oxidizing agent peroxynitrite (ONOO ). Peroxynitri